Chemogenetic Activation of Feed-Forward Inhibitory Parvalbumin-Expressing Interneurons in the Cortico-Thalamocortical Network During Absence Seizures

Chemogenetic Activation of Feed-Forward Inhibitory Parvalbumin-Expressing Interneurons in the Cortico-Thalamocortical Network During Absence Seizures

Parvalbumin-expressing (PV+) interneurons are a subset of GABAergic inhibitory interneurons that mediate feed-forward inhibition (FFI) within the cortico-thalamocortical (CTC) network of the brain. The CTC network is a reciprocal loop with connections between cortex and thalamus. FFI PV+ interneuron...

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Bibliographic Details
Main Authors: Sandesh Panthi, Beulah Leitch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cortico-thalamocortical
parvalbumin
GABAergic interneurons
feed-forward inhibition
DREADDs
absence seizures
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.688905/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.688905/full

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