Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells

Foxp3+ Regulatory and Conventional CD4+ T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells

Foxp3+ regulatory T cells (Tregs) play a major role in acquired immune tolerance to allogenic transplants. Their suppressive activity is thought to require T cell receptor (TCR)-driven antigen recognition; little, however, is known about the fraction of Tregs able to recognize alloantigens within th...

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Bibliographic Details
Main Authors: Mélanie Lalfer, Pascal Chappert, Maxime Carpentier, Dominique Urbain, Jean M. Davoust, David-Alexandre Gross
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
T cells
Foxp3+ regulatory T cells
TCR
alloreactivity
transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00521/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00521/full

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