Structural Basis for the Inhibition of SARS-CoV-2 M<sup>pro</sup> D48N Mutant by Shikonin and PF-07321332

Structural Basis for the Inhibition of SARS-CoV-2 M<sup>pro</sup> D48N Mutant by Shikonin and PF-07321332

Preventing the spread of SARS-CoV-2 and its variants is crucial in the fight against COVID-19. Inhibition of the main protease (M<sup>pro</sup>) of SARS-CoV-2 is the key to disrupting viral replication, making M<sup>pro</sup> a promising target for therapy. PF-07321332 and sh...

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Bibliographic Details
Main Authors: Zhenyu Zhao, Qinyao Zhu, Xuelan Zhou, Wenwen Li, Xiushan Yin, Jian Li
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Viruses
Subjects:
SARS-CoV-2
mutant
main protease
shikonin
PF-07321332
M<sup>pro</sup> inhibitor
Online Access:https://www.mdpi.com/1999-4915/16/1/65

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https://www.mdpi.com/1999-4915/16/1/65

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