Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.

Early retinal function deficit without prominent morphological changes in the R6/2 mouse model of Huntington's disease.

Huntington's disease (HD) is an inherited neurodegenerative disorder that primarily affects the medium-size GABAergic neurons of striatum. The R6/2 mouse line is one of the most widely used animal models of HD. Previously the hallmarks of HD-related pathology have been detected in photoreceptor...

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Main Authors: Symantas Ragauskas, Henri Leinonen, Jooseppi Puranen, Seppo Rönkkö, Soile Nymark, Kestutis Gurevicius, Arto Lipponen, Outi Kontkanen, Jukka Puoliväli, Heikki Tanila, Giedrius Kalesnykas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4254453?pdf=render

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http://europepmc.org/articles/PMC4254453?pdf=render

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