Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

Genetic polymorphism and evidence of signatures of selection in the Plasmodium falciparum circumsporozoite protein gene in Tanzanian regions with different malaria endemicity

Abstract Background In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission. These vaccines are made of Plasmodium falciparum circumsporozoite pro...

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Bibliographic Details
Main Authors: Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey, Deus S. Ishengoma
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Circumsporozoite protein
Malaria vaccine
Genetic diversity
Signature of selection
Tanzania
Online Access:https://doi.org/10.1186/s12936-024-04974-3

Internet

https://doi.org/10.1186/s12936-024-04974-3

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