Structure Activity Relationship Studies around <i><named-content content-type="color:blue">DB18</named-content></i>, a Potent and Selective Inhibitor of CLK Kinases
Three series of our lead CLK1 inhibitor <b><i>DB18</i></b> have been designed, synthetized and tested against CLKs and DYRK1A kinases. Their cytotoxicity was subsequently measured on seven representative cancer cell lines. Guided by docking experiments, we focused on the less...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-09-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/19/6149 |