Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme <i>Cyp46a1</i> on Behavior and Hippocampal Transcription in Mouse

Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme <i>Cyp46a1</i> on Behavior and Hippocampal Transcription in Mouse

Brain cholesterol metabolic products include neurosteroids and oxysterols, which play important roles in cellular physiology. In neurons, the cholesterol oxidation product, 24S-hydroxycholesterol (24S-HC), is a regulator of signaling and transcription. Here, we examined the behavioral effects of 24S...

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Bibliographic Details
Main Authors: Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomolecules
Subjects:
24S-hydroxycholesterol
oxysterol
liver X receptor
hippocampus
learning
Online Access:https://www.mdpi.com/2218-273X/14/3/254

Internet

https://www.mdpi.com/2218-273X/14/3/254

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