Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models

Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models

Background Limited persistence of functional CAR T cells in the immunosuppressive solid tumor microenvironment remains a major hurdle in the successful translation of CAR T cell therapy to treat solid tumors. Fine-tuning of CAR T cell activation by mutating CD3ζ chain immunoreceptor tyrosine-based a...

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Bibliographic Details
Main Authors: Thomas Poiret, Isabelle Magalhaes, Jonas Mattsson, Ying Zhao, Rui He, Esther Schoutrop, Ibrahim El-Serafi, Alina Moter, Johan Henriksson, Moustapha Hassan
Format: Article
Language:English
Published: BMJ Publishing Group 2023-02-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/2/e005691.full

Internet

https://jitc.bmj.com/content/11/2/e005691.full

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