PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models

PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models

Abstract Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to the pathogenesis of choroidal neovascularization (CNV) in exudative AMD (wet AMD)...

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Bibliographic Details
Main Authors: Pengfei Zhan, Yuqing Cui, Yujuan Cao, Xun Bao, Meili Wu, Qian Yang, Jiahui Yang, Haohan Zheng, Jian Zou, Tianhua Xie, Jiping Cai, Yong Yao, Xiaolu Wang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cell Communication and Signaling
Subjects:
PGE2
Neovascularization
Macrophage
AMD
Online Access:https://doi.org/10.1186/s12964-022-00973-6

Internet

https://doi.org/10.1186/s12964-022-00973-6

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