Differences in Charge Distribution in <i>Leishmania tarentolae</i> Leishmanolysin Result in a Reduced Enzymatic Activity

Differences in Charge Distribution in <i>Leishmania tarentolae</i> Leishmanolysin Result in a Reduced Enzymatic Activity

<i>Leishmania tarentolae</i> is a non-pathogenic trypanosomatid isolated from lizards widely used for heterologous protein expression and extensively studied to understand the pathogenic mechanisms of leishmaniasis. The repertoire of leishmanolysin genes was reported to be expanded in &l...

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Bibliographic Details
Main Authors: Vítor Ennes-Vidal, Deborah Antunes, Ester Poláková, Vyacheslav Yurchenko, Simone S. C. Oliveira, Fabio Faria da Mota, Ana Carolina R. Guimaraes, Ernesto R. Caffarena, André L. S. Santos, Marta H. Branquinha, Claudia M. d’Avila-Levy
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
proteolytic activity
leishmaniasis
cloning
comparative modeling
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/14/7660

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https://www.mdpi.com/1422-0067/23/14/7660

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