Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome

Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome

Background: Diabetic nephropathy (DN) is one of the leading causes of chronic kidney disease (CKD) worldwide, tubular injury is the driving force during the pathogenesis and progression of DN. Thus, we aim to utilize the connectivity map (CMap) with renal tubulointerstitial transcriptomic profiles o...

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Bibliographic Details
Main Authors: Qing Hou, Shuyan Kan, Zhuang Wang, Jinsong Shi, Caihong Zeng, Dahai Yang, Song Jiang, Zhihong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
connectivity map
diabetic nephropathy
HDAC6
NLRP3 inflammasome
tubular injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.938391/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.938391/full

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