Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature

Histological transformation of adenocarcinoma to small cell carcinoma lung as a rare mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors: Report of a case with review of literature

A subset of non-small cell lung carcinoma (NSCC) harbor active mutations of epidermal growth factor receptor (EGFR). In these, EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as the first-line treatment. Though drug resistance is inevitable, histological transformation to small cell lung...

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Bibliographic Details
Main Authors: Monalisa Hui, Shantveer G Uppin, Bala Joseph Stalin, G Sadashivudu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Lung India
Subjects:
Acquired resistance
epidermal growth factor receptor
histological transformation
nonsmall cell lung carcinoma
small cell lung carcinoma
tyrosine kinase inhibitor
Online Access:http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=2;spage=160;epage=163;aulast=Hui

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http://www.lungindia.com/article.asp?issn=0970-2113;year=2018;volume=35;issue=2;spage=160;epage=163;aulast=Hui

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