Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes

Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes

In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis. Connexin36 (Cx36) gap junctions electrically couple β-cells to coordinate glucose-stimulated Ca2+ and insulin secretion. Cx36 gap junction coupli...

Full description

Bibliographic Details
Main Authors: Nikki L. Farnsworth, Robert A. Piscopio, Wolfgang E. Schleicher, David G. Ramirez, Jose G. Miranda, Richard K. P. Benninger
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Physiology
Subjects:
calcium signaling
connexin36
cytokines
islet dysfunction
NOD mouse
type 1 diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.913611/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.913611/full

Similar Items