Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

Intestinal current measurement detects age-dependent differences in CFTR function in rectal epithelium

ObjectiveIntestinal current measurement (ICM) provides a sensitive bioassay for assessment of cystic fibrosis transmembrane conductance regulator (CFTR) function in rectal biopsies ex vivo and is used as a diagnostic tool for cystic fibrosis (CF). Furthermore, ICM was shown to be sensitive to detect...

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Bibliographic Details
Main Authors: Simon Y. Graeber, Olaf Sommerburg, Yin Yu, Julian Berges, Stephanie Hirtz, Heike Scheuermann, Jasmin Berger, Julia Duerr, Marcus A. Mall
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
CFTR
intestinal current measurement
rectal epithelium
age-dependency
CFTR modulator therapy
secretory diarrhea
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1537095/full

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https://www.frontiersin.org/articles/10.3389/fphar.2025.1537095/full

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