Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.

Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations.

We investigated the behavioral significance of fast synaptic inhibition by αβγ2-type GABA(A) receptors on parvalbumin (Pv) cells. The GABA(A) receptor γ2 subunit gene was selectively inactivated in Pv-positive neurons by Cre/loxP recombination. The resulting Pv-Δγ2 mice were relatively healthy in th...

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Bibliographic Details
Main Authors: Elli Leppä, Anni-Maija Linden, Olga Y Vekovischeva, Jerome D Swinny, Ville Rantanen, Esko Toppila, Harald Höger, Werner Sieghart, Peer Wulff, William Wisden, Esa R Korpi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3166293?pdf=render

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http://europepmc.org/articles/PMC3166293?pdf=render

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