Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Eicosanoid-Activated PPARα Inhibits NFκB-Dependent Bacterial Clearance During Post-Influenza Superinfection

Secondary bacterial infection (superinfection) post influenza is a serious clinical complication often leading to pneumonia and death. Eicosanoids are bioactive lipid mediators that play critical roles in the induction and resolution of inflammation. CYP450 lipid metabolites are anti-inflammatory li...

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Bibliographic Details
Main Authors: Ronald Lucarelli, Norma Gorrochotegui-Escalante, Jessica Taddeo, Bettina Buttaro, Joris Beld, Vincent Tam
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
influenza
Staphylococcus aureus
eicosanoid
Cytochrome P450
lipidomic
innate immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.881462/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.881462/full

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