Microenvironment Stiffness Amplifies Post-ischemia Heart Regeneration in Response to Exogenous Extracellular Matrix Proteins in Neonatal Mice

Microenvironment Stiffness Amplifies Post-ischemia Heart Regeneration in Response to Exogenous Extracellular Matrix Proteins in Neonatal Mice

The cardiogenesis of the fetal heart is absent in juveniles and adults. Cross-transplantation of decellularized extracellular matrix (dECM) can stimulate regeneration in myocardial infarct (MI) models. We have previously shown that dECM and tissue stiffness have cooperative regulation of heart regen...

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Bibliographic Details
Main Authors: Xinming Wang, Valinteshley Pierre, Subhadip Senapati, Paul S.-H. Park, Samuel E. Senyo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
heart regeneration
extracellular matrix
decellularization
microenvironment stiffness
myocardial infarction
cell cycle activity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.773978/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.773978/full

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