Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

Comprehensive identification of diverse ribosomal RNA modifications by targeted nanopore direct RNA sequencing and JACUSA2

Ribosomal RNAs are decorated by numerous post-transcriptional modifications whose exact roles in ribosome biogenesis, function, and human pathophysiology remain largely unknown. Here, we report a targeted direct rRNA sequencing approach involving a substrate selection step and demonstrate its suitab...

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Bibliographic Details
Main Authors: Isabel S. Naarmann-de Vries, Christiane Zorbas, Amina Lemsara, Michael Piechotta, Felix G. M. Ernst, Ludivine Wacheul, Denis L. J. Lafontaine, Christoph Dieterich
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:RNA Biology
Subjects:
rna modification
nanopore
direct rna-seq
ribosomal rna
rna methylation
cytidine acetylation
Online Access:http://dx.doi.org/10.1080/15476286.2023.2248752

Internet

http://dx.doi.org/10.1080/15476286.2023.2248752

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