Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models

Calibration-free PAT: Locating selective crystallization or precipitation sweet spot in screenings with multi-way PARAFAC models

When developping selective crystallization or precipitation processes, biopharmaceutical modalities require empirical screenings and analytics tailored to the specific needs of the target molecule. The multi-way chemometric approach called parallel factor analysis (PARAFAC) coupled with ultraviolet...

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Bibliographic Details
Main Authors: Christina Henriette Wegner, Jürgen Hubbuch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
selective precipitation
selective crystallization
multi-way chemometrics
parallel factor analysis (PARAFAC)
ultravioletvisible light (UV/Vis) spectroscopy
high-throughput (HT) screening
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1051129/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1051129/full

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