Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Pan-histone deacetylase inhibitor vorinostat suppresses osteoclastic bone resorption through modulation of RANKL-evoked signaling and ameliorates ovariectomy-induced bone loss

Abstract Background Estrogen deficiency-mediated hyperactive osteoclast represents the leading role during the onset of postmenopausal osteoporosis. The activation of a series of signaling cascades triggered by RANKL-RANK interaction is crucial mechanism underlying osteoclastogenesis. Vorinostat (SA...

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Bibliographic Details
Main Authors: Xiaole Peng, Tianhao Wang, Qing Wang, Yuhu Zhao, Hao Xu, Huilin Yang, Ye Gu, Yunxia Tao, Bangsheng Yan, Yaozeng Xu, Dechun Geng
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cell Communication and Signaling
Subjects:
Vorinostat
Osteoporosis
Osteoclastogenesis
RANKL
Online Access:https://doi.org/10.1186/s12964-024-01525-w

Internet

https://doi.org/10.1186/s12964-024-01525-w

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