A<sub>2A</sub> Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

A<sub>2A</sub> Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

The A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action are attractive tools for neurodegenerative disorders. In order to find novel A<sub>2A</...

Full description

Bibliographic Details
Main Authors: Andrea Spinaci, Catia Lambertucci, Michela Buccioni, Diego Dal Ben, Claudia Graiff, Maria Cristina Barbalace, Silvana Hrelia, Cristina Angeloni, Seyed Khosrow Tayebati, Massimo Ubaldi, Alessio Masi, Karl-Norbert Klotz, Rosaria Volpini, Gabriella Marucci
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
A<sub>2A</sub> adenosine receptor antagonists
purine derivatives
triazolotriazine derivatives
anti-Parkinson agents
anti-inflammatory agents
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/27/8/2386

Internet

https://www.mdpi.com/1420-3049/27/8/2386

Similar Items