A<sub>2A</sub> Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

A<sub>2A</sub> Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

The A<sub>2A</sub> adenosine receptor (A<sub>2A</sub>AR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action are attractive tools for neurodegenerative disorders. In order to find novel A<sub>2A</...

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Bibliographic Details
Main Authors:	Andrea Spinaci, Catia Lambertucci, Michela Buccioni, Diego Dal Ben, Claudia Graiff, Maria Cristina Barbalace, Silvana Hrelia, Cristina Angeloni, Seyed Khosrow Tayebati, Massimo Ubaldi, Alessio Masi, Karl-Norbert Klotz, Rosaria Volpini, Gabriella Marucci
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Series:	Molecules
Subjects:	A<sub>2A</sub> adenosine receptor antagonists purine derivatives triazolotriazine derivatives anti-Parkinson agents anti-inflammatory agents molecular modeling
Online Access:	https://www.mdpi.com/1420-3049/27/8/2386

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