Why Monoamine Oxidase B Preferably Metabolizes <i>N</i>-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step
Histamine levels in the human brain are controlled by rather peculiar metabolic pathways. In the first step, histamine is enzymatically methylated at its imidazole <i>N</i><sup>τ</sup> atom, and the produced <i>N</i>-methylhistamine undergoes an oxidative deaminat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/3/1910 |