Why Monoamine Oxidase B Preferably Metabolizes <i>N</i>-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step

Why Monoamine Oxidase B Preferably Metabolizes <i>N</i>-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step

Histamine levels in the human brain are controlled by rather peculiar metabolic pathways. In the first step, histamine is enzymatically methylated at its imidazole <i>N</i><sup>τ</sup> atom, and the produced <i>N</i>-methylhistamine undergoes an oxidative deaminat...

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Bibliographic Details
Main Authors: Aleksandra Maršavelski, Janez Mavri, Robert Vianello, Jernej Stare
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
histamine
<i>N</i>-methylhistamine
selectivity
metabolic pathway
monoamine oxidase B
rate constant
Online Access:https://www.mdpi.com/1422-0067/23/3/1910

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