Sex and Age Influence on Association of <i>CYP450</i> Polymorphism with Midazolam Levels in Critically Ill Children

Sex and Age Influence on Association of <i>CYP450</i> Polymorphism with Midazolam Levels in Critically Ill Children

Midazolam is a drug that is metabolized by cytochrome P450 (CYP450) enzymes, particularly CYP3A4 and CYP3A5. The present study aimed to determine the sex and age influence on association of CYP450 polymorphism with midazolam levels in critically ill children. Seventy-two DNA samples were genotyped b...

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Bibliographic Details
Main Authors: Carmen Flores-Pérez, Janett Flores-Pérez, Manuel de Jesús Castillejos López, Juan Luis Chávez-Pacheco, Karla Miroslava Tejada-Gutiérrez, Arnoldo Aquino-Gálvez, Luz María Torres-Espíndola
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Diagnostics
Subjects:
midazolam
cytochrome P-450 CYP3A
sex
pharmacokinetics
critically ill
pediatrics
Online Access:https://www.mdpi.com/2075-4418/12/11/2797

Internet

https://www.mdpi.com/2075-4418/12/11/2797

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