Low awareness of the transitivity assumption in complex networks of interventions: a systematic survey from 721 network meta-analyses

Abstract Background The transitivity assumption is the cornerstone of network meta-analysis (NMA). Violating transitivity compromises the credibility of the indirect estimates and, by extent, the estimated treatment effects of the comparisons in the network. The present study offers comprehensive em...

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Main Authors: Loukia M. Spineli, Chrysostomos Kalyvas, Juan Jose Yepes-Nuñez, Andrés Mauricio García-Sierra, Diana C. Rivera-Pinzón, Svenja E. Seide, Katerina Papadimitropoulou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12916-024-03322-1