Structure-based design of a dual-warhead covalent inhibitor of FGFR4

Structure-based design of a dual-warhead covalent inhibitor of FGFR4

Fibroblast growth factor receptor 4 (FGFR4) is a promising target for the treatment of hepatocellular carcinoma, but current FGFR4 covalent inhibitors target only one of the two cysteine residues (Cys477 or Cys552) that provide FGFR4-specificity. Here, a dual-warhead covalent FGFR4 inhibitor that ca...

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Bibliographic Details
Main Authors: Xiaojuan Chen, Huiliang Li, Qianmeng Lin, Shuyan Dai, Sitong Yue, Lingzhi Qu, Maoyu Li, Ming Guo, Hudie Wei, Jun Li, Longying Jiang, Guangyu Xu, Yongheng Chen
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-022-00657-9

Internet

https://doi.org/10.1038/s42004-022-00657-9

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