The Selection of Antibiotic- and Bacteriophage-Resistant Pseudomonas aeruginosa Is Prevented by Their Combination

The Selection of Antibiotic- and Bacteriophage-Resistant Pseudomonas aeruginosa Is Prevented by Their Combination

ABSTRACT Bacteria developing resistance compromise the efficacy of antibiotics or bacteriophages (phages). We tested the association of these two antibacterials to circumvent resistance. With the Hollow Fiber Infection Model (HFIM), we mimicked the concentration profile of ciprofloxacin in the lungs...

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Bibliographic Details
Main Authors: Aude A. Ferran, Marlène Z. Lacroix, Ophélie Gourbeyre, Alicia Huesca, Baptiste Gaborieau, Laurent Debarbieux, Alain Bousquet-Mélou
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
hollow fiber infection model
antimicrobial resistance
phage therapy
pharmacokinetics
drug combination
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02874-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02874-22

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