Parkin-Mediated Mitophagy by TGF-β Is Connected with Hepatic Stellate Cell Activation

Parkin-Mediated Mitophagy by TGF-β Is Connected with Hepatic Stellate Cell Activation

Hepatic stellate cells (HSCs) are the main contributors to the development and progression of liver fibrosis. Parkin is an E3 ligase involved in mitophagy mediated by lysosomes that maintains mitochondrial homeostasis. Unfortunately, there is little information regarding the regulation of parkin by...

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Bibliographic Details
Main Authors: Ji Hyun Lee, Kyu Min Kim, Eun Hee Jung, Hye Rim Lee, Ji Hye Yang, Sam Seok Cho, Sung Hwan Ki
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
liver fibrosis
hepatic stellate cell
mitophagy
parkin
Smad2
Online Access:https://www.mdpi.com/1422-0067/24/19/14826

Internet

https://www.mdpi.com/1422-0067/24/19/14826

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