Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

Abstract Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA methylation in cancer cells, the epigenetic mechanism underlying multidrug resistance...

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Bibliographic Details
Main Authors: Xiao-Jun Guo, Xiao-Yong Huang, Xuan Yang, Jia-Cheng Lu, Chuan-Yuan Wei, Chao Gao, Yan-Zi Pei, Yi Chen, Qi-Man Sun, Jia-Bin Cai, Jian Zhou, Jia Fan, Ai-Wu Ke, Yujiang G. Shi, Ying-Hao Shen, Peng-Fei Zhang, Guo-Ming Shi, Guo-Huan Yang
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05406-3

Internet

https://doi.org/10.1038/s41419-022-05406-3

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