Inhibition of calcium-sensing receptor by its antagonist promotes gastrointestinal motility in a Parkinson’s disease mouse model

Background: The Calcium-sensing receptor (CaSR) participates in the regulation of gastrointestinal (GI) motility under normal conditions and might be involved in the regulation of GI dysmotility in patients with Parkinson's disease (PD). Methods: CaSR antagonist-NPS-2143 was applied in in vivo...

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Main Authors: Yu-Hang Li, Zhong-Xin Jiang, Qian Xu, Ting-Ting Jin, Jin-Fang Huang, Xiao Luan, Chong Li, Xin-Yi Chen, Ka-Hing Wong, Xiao-Li Dong, Xiang-Rong Sun
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004025