<named-content content-type="genus-species">Brucella abortus</named-content> Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP

<named-content content-type="genus-species">Brucella abortus</named-content> Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP

ABSTRACT Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR). In the case of infection with Brucella abortus, the etiolog...

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Bibliographic Details
Main Authors: Mariana X. Byndloss, April Y. Tsai, Gregory T. Walker, Cheryl N. Miller, Briana M. Young, Bevin C. English, Núbia Seyffert, Tobias Kerrinnes, Maarten F. de Jong, Vidya L. Atluri, Maria G. Winter, Jean Celli, Renée M. Tsolis
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
Brucella
type IV secretion
effector functions
endoplasmic reticulum
placenta
trophoblast
Online Access:https://journals.asm.org/doi/10.1128/mBio.01538-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01538-19

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