NSAIDs: Old Drugs Reveal New Anticancer Targets

NSAIDs: Old Drugs Reveal New Anticancer Targets

There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemop...

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Bibliographic Details
Main Authors: Gary A. Piazza, Adam B. Keeton, Heather N. Tinsley, Jason D. Whitt, Bernard D. Gary, Bini Mathew, Raj Singh, William E. Grizzle, Robert C. Reynolds
Format: Article
Language:English
Published: MDPI AG 2010-05-01
Series:Pharmaceuticals
Subjects:
NSAIDs
sulindac
cancer
colon
chemoprevention
Online Access:http://www.mdpi.com/1424-8247/3/5/1652/

Internet

http://www.mdpi.com/1424-8247/3/5/1652/

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