Statistical analysis plan for stage 1 EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) study

Statistical analysis plan for stage 1 EMBARC (Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care) study

Antidepressant medications are commonly used to treat depression, but only about 30% of patients reach remission with any single first-step antidepressant. If the first-step treatment fails, response and remission rates at subsequent steps are even more limited. The literature on biomarkers for trea...

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Bibliographic Details
Main Authors: Eva Petkova, R. Todd Ogden, Thaddeus Tarpey, Adam Ciarleglio, Bei Jiang, Zhe Su, Thomas Carmody, Philip Adams, Helena C. Kraemer, Bruce D. Grannemann, Maria A. Oquendo, Ramin Parsey, Myrna Weissman, Patrick J. McGrath, Maurizio Fava, Madhukar H. Trivedi
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Contemporary Clinical Trials Communications
Subjects:
Combining biomarkers
Differential treatment response index
Moderator
Optimizing treatment decisions
Precision medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865416300412

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http://www.sciencedirect.com/science/article/pii/S2451865416300412

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