Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro techniques and pharmacokinetic analysis. The...

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Bibliographic Details
Main Authors: Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Alfredo Garcia-Arieta, Isabel González-Alvarez, Bart Hens, Gregory E. Amidon, Nair Rodriguez-Hornedo, Gordon L. Amidon, Deanna Mudie
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Pharmaceutics
Subjects:
gastrointestinal absorption
dexketoprofen
gastrointestinal simulator
microscopy imaging
liquid–liquid phase separation
oral absorption
in vitro dissolution
Online Access:http://www.mdpi.com/1999-4923/11/3/122

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http://www.mdpi.com/1999-4923/11/3/122

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