Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug product formulations of dexketoprofen trometamol (DKT) salt—Using a combination of in vitro techniques and pharmacokinetic analysis. The...

Full description

Bibliographic Details
Main Authors:	Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Alfredo Garcia-Arieta, Isabel González-Alvarez, Bart Hens, Gregory E. Amidon, Nair Rodriguez-Hornedo, Gordon L. Amidon, Deanna Mudie
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Pharmaceutics
Subjects:	gastrointestinal absorption dexketoprofen gastrointestinal simulator microscopy imaging liquid–liquid phase separation oral absorption in vitro dissolution
Online Access:	http://www.mdpi.com/1999-4923/11/3/122

Similar Items

An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products
by: Isabel Gonzalez-Alvarez, et al.
Published: (2021-04-01)

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP
by: Marival Bermejo, et al.
Published: (2020-01-01)

Development and validation of highly selective method for the determination of imatinib mesylate and dexketoprofen trometamol combination in three different media
by: Ozlem Coban, et al.
Published: (2020-09-01)

Comparing Early Postoperative Period Analgesic Effect of Dexketoprofene Trometamol and Lornoxicam in Mediastinoscopy Cases
by: Gonul Sagiroglu
Published: (2011-04-01)

Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect
by: Vicente Esparza-Villalpando, et al.
Published: (2018-07-01)

In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug
by: Isabel Gonzalez-Alvarez, et al.
Published: (2024-03-01)

Topical Chitosan-Based Thermo-Responsive Scaffold Provides Dexketoprofen Trometamol Controlled Release for 24 h Use
by: Luis Castillo-Henríquez, et al.
Published: (2021-12-01)

The impact of intravenously administered dexketoprofen trometamol on analgesia and recovery in ambulatory dilatation and curettage procedures: a retrospective analysis
by: Naime Yalçın, et al.
Published: (2022-10-01)

Immune modulation by dexketoprofen trometamol, a selective eicosanoid biosynthesis inhibitor of cellular immune response and phenoloxidase reaction in response to viral infection in Pimpla turionellae adults
by: Cihat Çelik
Published: (2024-09-01)

Evaluation of the Analgesic Efficacy of Dexketoprofen and Tramadol in Thyroid Surgery
by: Ayşe Çiğdem Tütüncü, et al.
Published: (2014-03-01)

Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b)
by: Bart Hens, et al.
Published: (2020-06-01)

Pain syndrome in oncology. Possibilities of dexketoprofen administration
by: M. V. Pchelintsev
Published: (2020-07-01)

Intravenous Dexketoprofen versus Intravenous Paracetamol for Dysmenorrhea: A Randomized Controlled Trial
by: Mustafa Serinken, et al.
Published: (2018-08-01)

Kounis Syndrome: Dexketoprofen-Associated ST-Elevation Myocardial Infarction
by: Aytekin Aksakal, et al.
Published: (2021-11-01)

Dexketoprofen – an additional opportunity to control chronic pain syndrome in malignant neoplasms
by: I. A. Koroleva
Published: (2019-06-01)

Efficacy of Intravenous Paracetamol, Dexketoprofen, and Ibuprofen in Treating Headache Induced by Acute Migraine Attack
by: Şerife Örnek, et al.
Published: (2024-03-01)

Development and Application of a Dissolution-Transfer-Partitioning System (DTPS) for Biopharmaceutical Drug Characterization
by: Christian Jede, et al.
Published: (2023-03-01)

Evaluation of Postoperative Anti-nociceptive Efficacy of Intrathecal Dexketoprofen in Rats
by: Birol Muhammet Er, et al.
Published: (2016-06-01)

Pain syndrome in medical practice therapeutic potential of dexketoprofen administration
by: G. G. Ketova, et al.
Published: (2019-04-01)

The effects of dexketoprofen on renal ischemia-reperfusion injury: an experimental study
by: Ersin Koksal, et al.
Published: (2022-05-01)

Dexketoprofen Trometamol and Tramadol Hydrochloride Fixed-Dose Combination in Moderate to Severe Acute Low Back Pain: A Phase IV, Randomized, Parallel Group, Placebo, Active-Controlled Study (DANTE)
by: Giustino Varrassi, et al.
Published: (2024-06-01)

Comparative chemoreactome analysis of dexketoprofen, ketoprofen, and diclofenac
by: I. Yu. Torshin, et al.
Published: (2018-04-01)

Dexketoprofen Pharmacokinetics is not Significantly Altered by Genetic Polymorphism
by: Gina Mejía-Abril, et al.
Published: (2021-04-01)

The effect of perioperative analgesic drugs omnopon and dexketoprofen on the functional activity of immune cells in murine model of tumor surgery
by: R. I. Sydor, et al.
Published: (2016-08-01)

Comparison of the Analgesic Effects of Intravenous Dexketoprofen, Ibuprofen and Fentanyl in Patients Suffering from Renal Colic Pain in the Emergency Department
by: Murat Özdemir, et al.
Published: (2023-03-01)

Preoperatively administered single dose of dexketoprofen decreases pain intensity on the first 5 days after craniotomy: A single-centre placebo-controlled, randomized trial
by: Simon Éva, et al.
Published: (2023-12-01)

Study on the influence of excipients on pharmaco-technological properties of tablet cores of dexketoprofen
by: O.V. Shoshmina, et al.
Published: (2019-03-01)

Cervicocranialgia: rationale for and evaluation of the clinical efficiency of therapy with the Russian generics of dexketoprofen and tolperisone
by: M. N. Dadasheva, et al.
Published: (2019-12-01)

Inhibition of Liquid–Liquid Phase Separation for Breaking the Solubility Barrier of Amorphous Solid Dispersions to Improve Oral Absorption of Naftopidil
by: Masafumi Fukiage, et al.
Published: (2022-11-01)

Development and validation of a stability-indicating HPLC method for the determination of buclizine hydrochloride in tablets and oral suspension and its application to dissolution studies
by: Gislaine Kuminek, et al.
Published: (2012-01-01)

Structure-based pharmacological screening, molecular docking and dynamic simulation reveals Dexketoprofen as a repurposable drug against Alzheimer's disease
by: Ishtiaque Ahammad, et al.
Published: (2023-01-01)

The Effects of Various Food Products on Bisphosphonate’s Availability
by: Monika Zielińska, et al.
Published: (2022-03-01)

Development of controlled release dexketoprofen tablets and prediction of drug release using Artificial Neural Network (ANN) modelling
by: Özlem Kışlal Saraçoğlu, et al.
Published: (2020-06-01)

Anaphylaxis after intravenous infusion of dexketoprofen trometamol
by: Sertac Guler, et al.
Published: (2016-09-01)

Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions
by: Kyosuke Suzuki, et al.
Published: (2021-02-01)

Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients
by: Isabel González-Álvarez, et al.
Published: (2022-11-01)

A new liquid phase microextraction method-based reverse micelle for analysis of dexketoprofen in human plasma by HPLC-DAD
by: Dönay Yuvali, et al.
Published: (2020-12-01)

Biowaiver as a Bioequivalence Study Option
by: E. A. Volkova, et al.
Published: (2024-02-01)

Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”
by: Takato Masada, et al.
Published: (2021-07-01)

Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water
by: Toshihide Takagi, et al.
Published: (2023-08-01)