Use of Pembrolizumab for Treatment of Progressive Multifocal Leukoencephalopathy in People Living with HIV

Use of Pembrolizumab for Treatment of Progressive Multifocal Leukoencephalopathy in People Living with HIV

Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating disease occurring in advanced HIV infection, caused by the reactivation of poliomavirus JC (JCV). The use of pembrolizumab for treatment is based on the inhibition of programmed cell death protein 1 (PD-1), potentially improving the...

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Bibliographic Details
Main Authors: Carmela Pinnetti, Eleonora Cimini, Alessandra Vergori, Valentina Mazzotta, Germana Grassi, Annalisa Mondi, Federica Forbici, Alessandra Amendola, Susanna Grisetti, Francesco Baldini, Caterina Candela, Rita Casetti, Paolo Campioni, Maria Rosaria Capobianchi, Chiara Agrati, Andrea Antinori
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
PML
advanced HIV-1
opportunistic infection
pembrolizumab
PD-1
JCV
Online Access:https://www.mdpi.com/1999-4915/14/5/970

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https://www.mdpi.com/1999-4915/14/5/970

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