Immune microenvironment profiling of normal appearing colorectal mucosa biopsied over repeat patient visits reproducibly separates lynch syndrome patients based on their history of colon cancer

Immune microenvironment profiling of normal appearing colorectal mucosa biopsied over repeat patient visits reproducibly separates lynch syndrome patients based on their history of colon cancer

IntroductionLynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC), increasing lifetime risk of CRC by up to 70%. Despite this higher lifetime risk, disease penetrance in LS patients is highly variable and most LS patients undergoing CRC surveillance will not develop CRC....

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Bibliographic Details
Main Authors: Rhonda M. Brand, Beth Dudley, Eve Karloski, Ashley Zyhowski, Rebecca Raphael, Danielle Pitlor, E. Jeffrey Metter, Reet Pai, Kenneth Lee, Randall E. Brand, Shikhar Uttam
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
Lynch syndrome
ex-vivo explant system
immune microenvironment
colorectal cancer
cytokines
biomarker selection
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1174831/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1174831/full

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