Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection

Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection

To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are negatively selected, however, divergence into tolerogenic, agonist selected lineages represent an alternative fate. As thymocyte development, selection, and lineage choices are dependent on spatial context and c...

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Bibliographic Details
Main Authors: Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Don Trinh, Michael Frisk, Karl-Andreas Dumont, Teodora Ribarska, Xavier Tekpli, Mario Saare, Benedicte Alexandra Lie
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
human thymus
autoimmunity
T cell development
T agonist selection
antigen-presenting cells
single-cell RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1092028/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1092028/full

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