Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid

Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid

Heart organoid (HO) technology has successfully overcome the limitations of two-dimensional (2D) disease modeling and drug testing, thereby emerging as a valuable tool in drug discovery for assessing toxicity and efficacy. However, its ability to distinguish drug responses among individuals remain u...

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Bibliographic Details
Main Authors: Jiye Jang, Hyewon Jung, Jaekyun Jeong, Junseok Jeon, Kyungho Lee, Hye Ryoun Jang, Jeung-Whan Han, Jaecheol Lee
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Doxorubicin-induced-cardiotoxicity
Induced pluripotent stem cell
Heart organoid
Disease modeling
Predictive model
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024147457

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http://www.sciencedirect.com/science/article/pii/S2405844024147457

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