Extensive breaking of genetic code degeneracy with non-canonical amino acids
Abstract Genetic code expansion (GCE) offers many exciting opportunities for the creation of synthetic organisms and for drug discovery methods that utilize in vitro translation. One type of GCE, sense codon reassignment (SCR), focuses on breaking the degeneracy of the 61 sense codons which encode f...
Main Authors: | Clinton A. L. McFeely, Bipasana Shakya, Chelsea A. Makovsky, Aidan K. Haney, T. Ashton Cropp, Matthew C. T. Hartman |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-40529-x |
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