Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle
With increasing global focus on planetary boundaries, food safety and quality, the presence of per- and polyfluoroalkyl substances (PFAS) in the food chain presents a challenge for the sustainable production and supply of quality assured food. Consumption of food is the primary PFAS exposure route f...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412023004919 |
| _version_ | 1797659921883332608 |
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| author | Antti T. Mikkonen Jennifer Martin Richard N. Upton Jan-Louis Moenning Jorge Numata Mark P. Taylor Michael S. Roberts Lorraine Mackenzie |
| author_facet | Antti T. Mikkonen Jennifer Martin Richard N. Upton Jan-Louis Moenning Jorge Numata Mark P. Taylor Michael S. Roberts Lorraine Mackenzie |
| author_sort | Antti T. Mikkonen |
| collection | DOAJ |
| description | With increasing global focus on planetary boundaries, food safety and quality, the presence of per- and polyfluoroalkyl substances (PFAS) in the food chain presents a challenge for the sustainable production and supply of quality assured food. Consumption of food is the primary PFAS exposure route for the general population. At contaminated sites, PFAS have been reported in a range of agricultural commodities including cattle. Consumer exposure assessments are complicated by the lack of validated modelling approaches to estimate PFAS bioaccumulation in cattle. Previous studies have shown that PFAS bioaccumulation in livestock is influenced by environmental, spatial and temporal factors that necessitate a dynamic modelling approach.This work presents an integrated exposure and population toxicokinetic (PopTK) model for cattle that estimates serum and tissue concentrations of PFAS over time. Daily exposures were estimated from intakes of water, pasture, and soil, and considered animal growth, seasonal variability (pasture moisture content and temperature) and variable PFAS concentrations across paddocks. Modelled serum and tissue estimates were validated against monitoring data from Australian and Swedish cattle farms. The models were also used to develop and test practical management options for reducing PFAS exposure and to prioritise remediation for farms. Model outputs for exposure management scenarios (testing cattle rotation and targeted supplementation of feed and water) showed potential for marked reductions in consumer exposures from cattle produce. |
| first_indexed | 2024-03-11T18:23:11Z |
| format | Article |
| id | doaj.art-8fb1281a18964b2481da29dc1bf2f3e0 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-03-11T18:23:11Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-8fb1281a18964b2481da29dc1bf2f3e02023-10-15T04:36:30ZengElsevierEnvironment International0160-41202023-10-01180108218Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattleAntti T. Mikkonen0Jennifer Martin1Richard N. Upton2Jan-Louis Moenning3Jorge Numata4Mark P. Taylor5Michael S. Roberts6Lorraine Mackenzie7University of South Australia, Clinical and Health Sciences, Adelaide, South Australia, Australia; Environment Protection Authority Victoria, EPA Science, Centre for Applied Sciences, Macleod, Victoria 3085 Australia; Corresponding author: University of South Australia, Clinical and Health Sciences, Adelaide, South Australia, Australia.Environment Protection Authority Victoria, EPA Science, Centre for Applied Sciences, Macleod, Victoria 3085 AustraliaUniversity of South Australia, Clinical and Health Sciences, Adelaide, South Australia, AustraliaGerman Federal Institute for Risk Assessment BfR, Department Safety in the Food Chain, Max-Dohrn-Str. 8-10, 10589 Berlin, GermanyGerman Federal Institute for Risk Assessment BfR, Department Safety in the Food Chain, Max-Dohrn-Str. 8-10, 10589 Berlin, GermanyEnvironment Protection Authority Victoria, EPA Science, Centre for Applied Sciences, Macleod, Victoria 3085 AustraliaUniversity of South Australia, Clinical and Health Sciences, Adelaide, South Australia, Australia; University of Queensland, Frazer Institute, Queensland, AustraliaUniversity of South Australia, Clinical and Health Sciences, Adelaide, South Australia, Australia; Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, AustraliaWith increasing global focus on planetary boundaries, food safety and quality, the presence of per- and polyfluoroalkyl substances (PFAS) in the food chain presents a challenge for the sustainable production and supply of quality assured food. Consumption of food is the primary PFAS exposure route for the general population. At contaminated sites, PFAS have been reported in a range of agricultural commodities including cattle. Consumer exposure assessments are complicated by the lack of validated modelling approaches to estimate PFAS bioaccumulation in cattle. Previous studies have shown that PFAS bioaccumulation in livestock is influenced by environmental, spatial and temporal factors that necessitate a dynamic modelling approach.This work presents an integrated exposure and population toxicokinetic (PopTK) model for cattle that estimates serum and tissue concentrations of PFAS over time. Daily exposures were estimated from intakes of water, pasture, and soil, and considered animal growth, seasonal variability (pasture moisture content and temperature) and variable PFAS concentrations across paddocks. Modelled serum and tissue estimates were validated against monitoring data from Australian and Swedish cattle farms. The models were also used to develop and test practical management options for reducing PFAS exposure and to prioritise remediation for farms. Model outputs for exposure management scenarios (testing cattle rotation and targeted supplementation of feed and water) showed potential for marked reductions in consumer exposures from cattle produce.http://www.sciencedirect.com/science/article/pii/S0160412023004919Perfluorooctane sulfonate (PFOS)CattleDynamic exposureToxicocokineticsFood chainRisk management |
| spellingShingle | Antti T. Mikkonen Jennifer Martin Richard N. Upton Jan-Louis Moenning Jorge Numata Mark P. Taylor Michael S. Roberts Lorraine Mackenzie Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle Environment International Perfluorooctane sulfonate (PFOS) Cattle Dynamic exposure Toxicocokinetics Food chain Risk management |
| title | Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle |
| title_full | Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle |
| title_fullStr | Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle |
| title_full_unstemmed | Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle |
| title_short | Dynamic exposure and body burden models for per- and polyfluoroalkyl substances (PFAS) enable management of food safety risks in cattle |
| title_sort | dynamic exposure and body burden models for per and polyfluoroalkyl substances pfas enable management of food safety risks in cattle |
| topic | Perfluorooctane sulfonate (PFOS) Cattle Dynamic exposure Toxicocokinetics Food chain Risk management |
| url | http://www.sciencedirect.com/science/article/pii/S0160412023004919 |
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