The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants

The crosstalk between FGF21 and GH leads to weakened GH receptor signaling and IGF1 expression and is associated with growth failure in very preterm infants

BackgroundFibroblast growth factor 21 (FGF21) is an essential metabolic regulator that adapts to changes in nutritional status. Severe childhood undernutrition induces elevated FGF21 levels, contributing to growth hormone (GH) resistance and subsequent linear growth attenuation potentially through a...

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Bibliographic Details
Main Authors: Jayna N. Mistry, Sanna Silvennoinen, Farasat Zaman, Lars Sävendahl, Katia Mariniello, Charlotte Hall, Sasha R. Howard, Leo Dunkel, Ulla Sankilampi, Leonardo Guasti
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Endocrinology
Subjects:
GH signaling
GH resistance
FGF21
growth plate
preterm infants
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1105602/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1105602/full

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