Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles

Abstract Background The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis. The role of RhoA in BPH remains unclear. Methods This study aimed to clarify the...

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Bibliographic Details
Main Authors: Shidong Shan, Min Su, Yan Li, Zhen Wang, Daoquan Liu, Yongying Zhou, Xun Fu, Shu Yang, Junchao Zhang, Jizhang Qiu, Huan Liu, Guang Zeng, Ping Chen, Xinghuan Wang, Michael E. DiSanto, Yuming Guo, Xinhua Zhang
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Molecular Medicine
Subjects:
Benign prostatic hyperplasia
RhoA-ROCK
β-catenin
Contraction
Cell growth
Online Access:https://doi.org/10.1186/s10020-023-00734-2

Internet

https://doi.org/10.1186/s10020-023-00734-2

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