Identification of speckle-type POZ protein somatic mutations in African American prostate cancer

Identification of speckle-type POZ protein somatic mutations in African American prostate cancer

The speckle-type POZ protein (SPOP) is a tumor suppressor in prostate cancer (PCa). SPOP somatic mutations have been reported in up to 15% of PCa of those of European descent. However, the genetic roles of SPOP in African American (AA)-PCa are currently unknown. We sequenced the SPOP gene to identif...

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Bibliographic Details
Main Authors: Eric Buckles, Chiping Qian, Andrew Tadros, Sumana Majumdar, Jennifer Cvitanovic, Jovanny Zabaleta, John Estrada, John Wilson, Wanguo Liu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-12-01
Series:Asian Journal of Andrology
Subjects:
African American; mutation analysis; prostate cancer; speckle-type POZ protein
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=6;spage=829;epage=832;aulast=Buckles

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=6;spage=829;epage=832;aulast=Buckles

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