Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Total Syntheses of Pladienolide-Derived Spliceosome Modulators

Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synth...

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Bibliographic Details
Main Authors: Jaehoon Sim, Eunbin Jang, Hyun Jin Kim, Hongjun Jeon
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
pladienolide class
spliceosome
total synthesis
natural products
macrocycles
Online Access:https://www.mdpi.com/1420-3049/26/19/5938

Internet

https://www.mdpi.com/1420-3049/26/19/5938

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