Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.

The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with adenoviral vectors. Here we investigated the IFN-alphabeta response to human aden...

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Main Authors: György Fejer, Lisa Drechsel, Jan Liese, Ulrike Schleicher, Zsolt Ruzsics, Nicola Imelli, Urs F Greber, Simone Keck, Bernd Hildenbrand, Anne Krug, Christian Bogdan, Marina A Freudenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2576454?pdf=render

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http://europepmc.org/articles/PMC2576454?pdf=render

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