Structural basis for germline antibody recognition of HIV-1 immunogens

Structural basis for germline antibody recognition of HIV-1 immunogens

Efforts to elicit broadly neutralizing antibodies (bNAbs) against HIV-1 require understanding germline bNAb recognition of HIV-1 envelope glycoprotein (Env). The VRC01-class bNAb family derived from the VH1-2*02 germline allele arose in multiple HIV-1–infected donors, yet targets the CD4-binding sit...

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Bibliographic Details
Main Authors: Louise Scharf, Anthony P West Jr, Stuart A Sievers, Courtney Chen, Siduo Jiang, Han Gao, Matthew D Gray, Andrew T McGuire, Johannes F Scheid, Michel C Nussenzweig, Leonidas Stamatatos, Pamela J Bjorkman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
HIV
broadly neutralizing antibodies
crystallography
Online Access:https://elifesciences.org/articles/13783

Internet

https://elifesciences.org/articles/13783

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