Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function
Given that the polysaccharide of Quinoa (Chenopodium quinoa Willd., QP) exhibited preliminarily antioxidant activity in our previous studies, herein its anti-aging activities being associated with the antioxidant effect were evaluated in vitro and in vivo. A series of characterization including 1H N...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622001670 |
| _version_ | 1817968132082368512 |
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| author | Yichen Hu Jie Zhou Yanan Cao Jinming Zhang Liang Zou |
| author_facet | Yichen Hu Jie Zhou Yanan Cao Jinming Zhang Liang Zou |
| author_sort | Yichen Hu |
| collection | DOAJ |
| description | Given that the polysaccharide of Quinoa (Chenopodium quinoa Willd., QP) exhibited preliminarily antioxidant activity in our previous studies, herein its anti-aging activities being associated with the antioxidant effect were evaluated in vitro and in vivo. A series of characterization including 1H NMR spectra, FT-IR spectra, and monosaccharide composition analysis, were implemented, indicated that homogalacturonans might exist as the major polysaccharide fraction in QP. The in vitro antioxidant assay demonstrated that QP had superior scavenging activities on DPPH and ABTS+. Oral administration of QP (100, 400, and 800 mg·kg−1) to D-galactose-induced mice significantly ameliorated the learning and memory of aging mice in the Morris water maze test. Meanwhile, QP could alleviate oxidative stress in brain and liver tissues, possibly related to an increase in antioxidant enzymes, reduction of lipid peroxidation, and restoration of lipid metabolism. The anti-aging effects of QP may involve the regulation of SITR1-associated target proteins including DBC1, p53, and Foxo3a in brain tissues. Overall, we demonstrate that QP would be a promising dietary supplement, which benefit to prevent aging and improve memory as well as cognitive function. |
| first_indexed | 2024-04-13T20:05:02Z |
| format | Article |
| id | doaj.art-8fbe4f76ca7a49fc84efcfae5fff4885 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T20:05:02Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8fbe4f76ca7a49fc84efcfae5fff48852022-12-22T02:32:04ZengElsevierJournal of Functional Foods1756-46462022-07-0194105097Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive functionYichen Hu0Jie Zhou1Yanan Cao2Jinming Zhang3Liang Zou4Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, People’s Republic of ChinaKey Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, People’s Republic of ChinaKey Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, People’s Republic of ChinaState Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, People’s Republic of China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan Province, People’s Republic of China (J. Zhang). Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, No .2025 Chengluo Avenue, Chengdu 610106, Sichuan Province, People’s Republic of China (L. Zou).Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, People’s Republic of China; Corresponding authors at: State Key Laboratory of Southwestern Chinese Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan Province, People’s Republic of China (J. Zhang). Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, No .2025 Chengluo Avenue, Chengdu 610106, Sichuan Province, People’s Republic of China (L. Zou).Given that the polysaccharide of Quinoa (Chenopodium quinoa Willd., QP) exhibited preliminarily antioxidant activity in our previous studies, herein its anti-aging activities being associated with the antioxidant effect were evaluated in vitro and in vivo. A series of characterization including 1H NMR spectra, FT-IR spectra, and monosaccharide composition analysis, were implemented, indicated that homogalacturonans might exist as the major polysaccharide fraction in QP. The in vitro antioxidant assay demonstrated that QP had superior scavenging activities on DPPH and ABTS+. Oral administration of QP (100, 400, and 800 mg·kg−1) to D-galactose-induced mice significantly ameliorated the learning and memory of aging mice in the Morris water maze test. Meanwhile, QP could alleviate oxidative stress in brain and liver tissues, possibly related to an increase in antioxidant enzymes, reduction of lipid peroxidation, and restoration of lipid metabolism. The anti-aging effects of QP may involve the regulation of SITR1-associated target proteins including DBC1, p53, and Foxo3a in brain tissues. Overall, we demonstrate that QP would be a promising dietary supplement, which benefit to prevent aging and improve memory as well as cognitive function.http://www.sciencedirect.com/science/article/pii/S1756464622001670QuinoaPolysaccharideAnti-agingD-galactoseCognitive function |
| spellingShingle | Yichen Hu Jie Zhou Yanan Cao Jinming Zhang Liang Zou Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function Journal of Functional Foods Quinoa Polysaccharide Anti-aging D-galactose Cognitive function |
| title | Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function |
| title_full | Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function |
| title_fullStr | Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function |
| title_full_unstemmed | Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function |
| title_short | Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function |
| title_sort | anti aging effects of polysaccharides from quinoa chenopodium quinoa willd in improving memory and cognitive function |
| topic | Quinoa Polysaccharide Anti-aging D-galactose Cognitive function |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622001670 |
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