Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.

The cellular serine protease TMPRSS2, a member of the type II transmembrane serine protease (TTSP) family, cleaves and activates the hemagglutinin of influenza A viruses (FLUAV) in cell culture and is essential for spread of diverse FLUAV in mice. Non-human primates (NHP), in particular rhesus and c...

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Main Authors: Pawel Zmora, Paulina Molau-Blazejewska, Stephanie Bertram, Kerstin Walendy-Gnirß, Inga Nehlmeier, Anika Hartleib, Anna-Sophie Moldenhauer, Sebastian Konzok, Susann Dehmel, Katherina Sewald, Constantin Brinkmann, Christoph Curths, Sascha Knauf, Jens Gruber, Kerstin Mätz-Rensing, Franziska Dahlmann, Armin Braun, Stefan Pöhlmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5426610?pdf=render

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http://europepmc.org/articles/PMC5426610?pdf=render

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